Quantitative analysis of hydroxylated polymethoxyflavones by high‐performance liquid chromatography
Identifieur interne : 001B68 ( Main/Exploration ); précédent : 001B67; suivant : 001B69Quantitative analysis of hydroxylated polymethoxyflavones by high‐performance liquid chromatography
Auteurs : Shiming Li [États-Unis] ; Yu Wang [États-Unis] ; Zhenyu Wang [États-Unis] ; Hang Xiao [États-Unis] ; Chih-Yu Lo [Taïwan] ; Nancy Rawson [États-Unis] ; Chi-Tang Ho [États-Unis]Source :
- Biomedical Chromatography [ 0269-3879 ] ; 2010-08.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Flavonoids, Plant Extracts.
- chemistry : Citrus sinensis.
- methods : Chromatography, High Pressure Liquid.
- Hydroxylation.
Abstract
Since the hydroxylated polymethoxyflavones were isolated from orange and other citrus peels, they have been found to exhibit potent anti‐cancer and anti‐inflammatory activities. Hydroxylated polymethoxyflavones, especially 5‐demethylnobiletin and 5‐hydroxy‐3,6,7,8,3′,4′‐hexamethoxyflavone, exert more potent activities than their counterpart polymethoxyflavones (PMFs). These findings have led to a new era of exploration of hydroxylated polymethoxyflavones and PMFs from the citrus genus for their potential application in nutraceutical, pharmaceuticals and functional foods. A practical and efficient analytical method for quantitatively characterizing the composition of PMFs has only recently been developed, and has applications both in academic research laboratories and quality controls. However, chemical analyses of the hydroxylated polymethoxyflavones have not been previously described. This paper reports the quantitative analysis of six 5‐demethylated PMFs in various commercial orange peel extracts, using high‐performance liquid chromatography with UV detection. Copyright © 2009 John Wiley & Sons, Ltd.
Url:
DOI: 10.1002/bmc.1372
Affiliations:
- Taïwan, États-Unis
- Massachusetts, New Jersey
- Amherst (Massachusetts), New Brunswick (New Jersey)
- Université Rutgers, Université du Massachusetts à Amherst
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Le document en format XML
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Hydroxylated polymethoxyflavones, especially 5‐demethylnobiletin and 5‐hydroxy‐3,6,7,8,3′,4′‐hexamethoxyflavone, exert more potent activities than their counterpart polymethoxyflavones (PMFs). These findings have led to a new era of exploration of hydroxylated polymethoxyflavones and PMFs from the citrus genus for their potential application in nutraceutical, pharmaceuticals and functional foods. A practical and efficient analytical method for quantitatively characterizing the composition of PMFs has only recently been developed, and has applications both in academic research laboratories and quality controls. However, chemical analyses of the hydroxylated polymethoxyflavones have not been previously described. This paper reports the quantitative analysis of six 5‐demethylated PMFs in various commercial orange peel extracts, using high‐performance liquid chromatography with UV detection. Copyright © 2009 John Wiley & Sons, Ltd.</div></front></TEI><affiliations><list><country><li>Taïwan</li><li>États-Unis</li></country><region><li>Massachusetts</li><li>New Jersey</li></region><settlement><li>Amherst (Massachusetts)</li><li>New Brunswick (New Jersey)</li></settlement><orgName><li>Université Rutgers</li><li>Université du Massachusetts à Amherst</li></orgName></list><tree><country name="États-Unis"><region name="New Jersey"><name sortKey="Li, Shiming" sort="Li, Shiming" uniqKey="Li S" first="Shiming" last="Li">Shiming Li</name></region><name sortKey="Ho, Chi Ang" sort="Ho, Chi Ang" uniqKey="Ho C" first="Chi-Tang" last="Ho">Chi-Tang Ho</name><name sortKey="Rawson, Nancy" sort="Rawson, Nancy" uniqKey="Rawson N" first="Nancy" last="Rawson">Nancy Rawson</name><name sortKey="Wang, Yu" sort="Wang, Yu" uniqKey="Wang Y" first="Yu" last="Wang">Yu Wang</name><name sortKey="Wang, Zhenyu" sort="Wang, Zhenyu" uniqKey="Wang Z" first="Zhenyu" last="Wang">Zhenyu Wang</name><name sortKey="Xiao, Hang" sort="Xiao, Hang" uniqKey="Xiao H" first="Hang" last="Xiao">Hang Xiao</name></country><country name="Taïwan"><noRegion><name sortKey="Lo, Chih U" sort="Lo, Chih U" uniqKey="Lo C" first="Chih-Yu" last="Lo">Chih-Yu Lo</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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